Hydrogen peroxide induces DNA single strand breaks in respiratory epithelial cells

@article{Mcdonald1993HydrogenPI,
  title={Hydrogen peroxide induces DNA single strand breaks in respiratory epithelial cells},
  author={Ruth J Mcdonald and Lester C. Pan and Judith A. St. George and Dallas M. Hyde and Jonathan M. Ducore},
  journal={Inflammation},
  year={1993},
  volume={17},
  pages={715-722}
}
The respiratory epithelium is often exposed to oxidant gases, including ozone from photochemical smog and toxic oxygen metabolites released from neutrophils recruited in conditions of airway inflammation. We evaluated DNA single strand break formation by alkaline elution as a measure of oxidant-induced DNA damage to bronchial epithelial cells. Human AdenoSV-40-transformed bronchial epithelial cells (BEAS), subclone R1.4 or nonhuman primate bronchial epithelial cells were cultured in growth… CONTINUE READING

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