Hydrogen-peroxide-induced toxicity of rat striatal neurones involves activation of a non-selective cation channel.

@article{Smith2003HydrogenperoxideinducedTO,
  title={Hydrogen-peroxide-induced toxicity of rat striatal neurones involves activation of a non-selective cation channel.},
  author={M A Smith and Paco S. Herson and Kyubeck Lee and Robert D. Pinnock and Michael L J Ashford},
  journal={The Journal of physiology},
  year={2003},
  volume={547 Pt 2},
  pages={417-25}
}
Striatal neurones are particularly vulnerable to hypoxia/ischaemia-induced damage, and free radicals are thought to be prime mediators of this neuronal destruction. It has been shown that hydrogen peroxide (H2O2), through the production of free radicals, induces rat insulinoma cell death by activation of a non-selective cation channel, which leads to irreversible cell depolarization and unregulated Ca2+ entry into the cell. In the study presented here, we demonstrate that a subpopulation of… CONTINUE READING
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