Hydrogen peroxide-induced cellular injury is associated with increase in endogenous fluorescence from rat gastric mucosal epithelial cell culture: A new method for detecting oxidative cellular injury by fluorescence measurement

@article{Matsui1998HydrogenPC,
  title={Hydrogen peroxide-induced cellular injury is associated with increase in endogenous fluorescence from rat gastric mucosal epithelial cell culture: A new method for detecting oxidative cellular injury by fluorescence measurement},
  author={Hirofumi Matsui and Yasushi Murata and Ken-ichi Hirano and Tetsuji Sasaki and Reiko Shiba and Hiroshi Muto and Tadao Ohno},
  journal={Journal of Gastroenterology},
  year={1998},
  volume={33},
  pages={318-325}
}
To develop a new method of detecting cellular injury caused by oxygen radicals, we studied endogenous fluorescence from the cultured cells of a rat gastric mucosal epithelial cell line. Measurement with an ultra-high sensitivity camera-image processor system under an inverted epifluorescence microscope showed that the fluorescence intensity of the cells increased time- and dose-dependently after the addition of hydrogen peroxide (H2O2), an oxygen radical precursor, to the medium. This increase… CONTINUE READING
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