Hydrogen peroxide-induced arachidonic acid release in L929 cells; roles of Src, protein kinase C and cytosolic phospholipase A2α

@article{Taniguchi2006HydrogenPA,
  title={Hydrogen peroxide-induced arachidonic acid release in L929 cells; roles of Src, protein kinase C and cytosolic phospholipase A2$\alpha$},
  author={Tomoko Taniguchi and Masaya Shimizu and Hiroyuki Nakamura and Tetsuya Hirabayashi and Hiromichi Fujino and Toshihiko Murayama},
  journal={European Journal of Pharmacology},
  year={2006},
  volume={546},
  pages={1-10}
}
Vanadate-induced activation of cytosolic phospholipase A2alpha in L929 cells: Roles of tyrosine kinase, protein kinase C, and extracellular signal-regulated kinase.
TLDR
Roles of alpha-type cytosolic phospholipase A2 (cPLA2alpha), Src family kinases (Src) and protein kinase C (PKC) in the release of AA induced by Na3VO4 from a murine fibroblast cell line, L929, are investigated.
Release of arachidonic acid induced by tumor necrosis factor-alpha in the presence of caspase inhibition: evidence for a cytosolic phospholipase A2alpha-independent pathway.
TLDR
TNFalpha/zVAD appears to stimulate release of AA from C12 cells in a cPLA(2)alpha-independent, BHA-sensitive manner and reactive oxygen species from different pools in the release ofAA and cell death were discussed.
Activation of cytosolic phospholipase A2alpha by epidermal growth factor (EGF) and phorbol ester in HeLa cells: different effects of inhibitors for EGF receptor, protein kinase C, Src, and C-Raf.
TLDR
Parmacological experiments showed that the responses (ERK phosphorylation and AA release) induced by EGF and PMA were mediated by a mitogen-activated protein kinase/ERK kinase (MEK)-ERK-alpha-type cytosolic phospholipase A(2) (cPLA( 2)alpha) pathway and that EGFR couples with the pathway in a manner insensitive to sorafenib.
Lactosylceramide‐Induced Phosphorylation Signaling to Group IVA Phospholipase A2 via Reactive Oxygen Species in Tumor Necrosis Factor‐α‐Treated Cells
TLDR
Investigation of the role of phosphorylation signaling in the TNFα/LacCer‐induced activation of cPLA2α in cells showed that LacCer alone simultaneously stimulates two processes to activate c PLA2α: a phosphorylated signal and attachment of the enzyme to substrate membranes.
Ser515 phosphorylation-independent regulation of cytosolic phospholipase A2alpha (cPLA2alpha) by calmodulin-dependent protein kinase: possible interaction with catalytic domain A of cPLA2alpha.
TLDR
Findings show a possible effect of CaM kinase on cPLA(2)alpha in a catalytic domain A-dependent and Ser515-independent manner.
Effects of synthetic sphingosine-1-phosphate analogs on cytosolic phospholipase A2alpha-independent release of arachidonic acid and cell toxicity in L929 fibrosarcoma cells: the structure-activity relationship.
TLDR
Synthetic phosphorylated lipid analogs may be useful for studying PLA(2) activity and its toxicity in cells, and a high correlation coefficient was observed.
Cytotoxicity induced by inhibition of thioredoxin reductases via multiple signaling pathways: Role of cytosolic phospholipase A2α‐dependent and ‐independent release of arachidonic acid
TLDR
The data suggest that a dysfunctional Trx system triggers multiple signaling pathways, and that the AA released by cPLA2α‐dependent and ‐independent pathways is important to cytotoxicity.
Effects of Hsp 90 inhibitors , geldanamycin and its analog , on ceramide metabolism and cytotoxicity in PC 12 cells
The inhibitors of heat shock protein-90 (Hsp90), geldanamycin (GA) and 17-(allylamino)17-desmethoxygeldanamycin, show various cellular effects including destabilization of Hsp90 clients and
Effects of Hsp90 inhibitors, geldanamycin and its analog, on ceramide metabolism and cytotoxicity in PC12 cells.
TLDR
The results suggest the possible involvement of ceramide metabolism, not AA release, in GA-induced cytotoxicity in PC12 cells.
Sinalização não-genômica do retinol mediada por espécies reativas
The biological effects of vitamin A (retinol) are generally ascribed to the activation of nuclear retinoid receptors by retinoic acid (RA), considered the most biologically active retinoid. However,
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References

SHOWING 1-10 OF 39 REFERENCES
Expression of cytosolic phospholipase A2 alpha in murine C12 cells, a variant of L929 cells, induces arachidonic acid release in response to phorbol myristate acetate and Ca2+ ionophores, but not to tumor necrosis factor-alpha.
TLDR
Results suggest that C12 cells may lack the components necessary for TNFalpha-induced AA release, in addition to cPLA2alpha, and the role of Ser505 phosphorylation in AA release induced by PMA is discussed.
Ceramide-1-phosphate activates cytosolic phospholipase A2alpha directly and by PKC pathway.
TLDR
It is proposed that C1P stimulates AA release via two mechanisms; direct activation of cPLA2alpha, and the PKC-dependent pathway.
Inhibition of hydrogen peroxide-induced apoptosis but not arachidonic acid release in GH3 cell by EGF
TLDR
It is suggested that treatment with EGF protects H2O2- and AA- and mastoparan-induced GH3 cell death and stimulates AA release via activation of cytosolic PLA2, and induces apoptotic death of GH3 cells.
Enhancement of arachidonic acid release and prostaglandin F(2alpha) formation by Na3VO4 in PC12 cells and GH3 cells.
TLDR
Findings suggest that the tyrosine phosphorylation pathway regulates arachidonic acid release by phospholipase A2 and prostaglandin F(2alpha) formation in neuronal cells.
Involvement of Calcium-independent Phospholipase A2in Hydrogen Peroxide-induced Accumulation of Free Fatty Acids in Human U937 Cells*
TLDR
These studies underscore the importance of the iPLA2 in modulating homeostatic fatty acid deacylation reactions and document a potentially important route under pathophysiological conditions for increasing free fatty acid levels during oxidative stress.
Phospholipase A2 Is Necessary for Tumor Necrosis Factor α-induced Ceramide Generation in L929 Cells*
TLDR
The introduction of the cPLA2 gene into C12 cells resulted in partial restoration of TNFα-induced arachidonate release, ceramide accumulation, and cytotoxicity, suggesting that c PLA2 is a necessary component in the pathways leading to ceramic accumulation and cell death.
Arachidonic Acid Release from Mammalian Cells Transfected with Human Groups IIA and X Secreted Phospholipase A2 Occurs Predominantly during the Secretory Process and with the Involvement of Cytosolic Phospholipase A2-α*
TLDR
Results along with additional data resolve the paradox that efficient arachidonic acid release occurs with h GIIA-transfected cells, and yet exogenously added hGIIA is poorly able to liberate arachidonate from mammalian cells.
Role of Ca2+-independent phospholipase A2 on arachidonic acid release induced by reactive oxygen species.
TLDR
iPLA2 activity is involved in the mechanism by which ROS increases the availability of free AA in macrophages RAW 264.7, suggesting this is a regulatory role of iPLA2.
Decrease in cytosolic phospholipase A2alpha mRNA levels by reactive oxygen species via MAP kinase pathways in PC12 cells: effects of dopaminergic neurotoxins.
TLDR
It is suggested that ROS decreases cPLA2alpha mRNA levels via MAPK pathways in PC12 cells in PC 12 cells via N-acetyl-cysteine and selective inhibitors of mitogen-activated protein kinase (MAPK) pathways (extracellular signal-regulated kinase and p38 MAPK).
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