Hydrogen peroxide-induced apoptosis mediated by p53 protein in glial cells.

@article{Kitamura1999HydrogenPA,
  title={Hydrogen peroxide-induced apoptosis mediated by p53 protein in glial cells.},
  author={Yoshihisa Kitamura and Tsuyoshi Ota and Yasuji Matsuoka and Ikuo Tooyama and Hiroto Kimura and Shun Shimohama and Yasuyuki Nomura and Peter J. Gebicke-haerter and Taketoshi Taniguchi},
  journal={Glia},
  year={1999},
  volume={25 2},
  pages={
          154-64
        }
}
It is now generally accepted that massive neuronal death due to oxidative stress is a regular feature of brains in neurodegenerative diseases. However, much less attention has been given to the death of glial cells. In this study, we examined p53-sensitive apoptosis of cells by using human glioblastoma A172 cells and p53-deficient mouse astrocytes. In human A172 cells, hydrogen peroxide (H2O2) caused cell death in a time- and concentration-dependent manner, accompanied by nucleosomal DNA… CONTINUE READING
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