Hydrogen peroxide generation in peroxisome proliferator-induced oncogenesis.

  title={Hydrogen peroxide generation in peroxisome proliferator-induced oncogenesis.},
  author={Anjana V. Yeldandi and M. Sambasiva Rao and Janardan K. Reddy},
  journal={Mutation research},
  volume={448 2},
Peroxisome proliferators are a structurally diverse group of non-genotoxic chemicals that induce predictable pleiotropic responses including the development of liver tumors in rats and mice. These chemicals interact variably with peroxisome proliferator-activated receptors (PPARs), which are members of the nuclear receptor superfamily. Evidence derived from mice with PPARalpha gene disruption indicates that of the three PPAR isoforms (alpha, beta/delta and gamma), the isoform PPARalpha is… CONTINUE READING