Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes.

@article{Mahadev2001HydrogenPG,
  title={Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes.},
  author={Kalyankar Mahadev and Xiufeng Wu and Assaf Zilbering and Ling Zhu and John Todd R. Lawrence and Barry J. Goldstein},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 52},
  pages={48662-9}
}
In a variety of cell types, insulin stimulation elicits the rapid production of H(2)O(2), which causes the oxidative inhibition of protein-tyrosine phosphatases and enhances the tyrosine phosphorylation of proteins in the early insulin action cascade (Mahadev, K., Zilbering, A., Zhu, L., and Goldstein, B. J. (2001) J. Biol. Chem. 276, 21938-21942). In the present work, we explored the potential role of insulin-induced H(2)O(2) generation on downstream insulin signaling using diphenyleneiodonium… CONTINUE READING
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