Hydrogen peroxide enhances osteopontin expression and matrix metalloproteinase activity in aortic vascular smooth muscle cells.

@article{Hu2009HydrogenPE,
  title={Hydrogen peroxide enhances osteopontin expression and matrix metalloproteinase activity in aortic vascular smooth muscle cells.},
  author={Tao Hu and Ronghua Luan and Haifeng Zhang and Wayne Bond Lau and Qiong Wang and Yao Zhang and Hai-Chang Wang and Ling Jie Tao},
  journal={Clinical and experimental pharmacology & physiology},
  year={2009},
  volume={36 7},
  pages={
          626-30
        }
}
1. Restenosis after percutaneous coronary intervention (PCI) is a major clinical complication. However, the underlying mechanisms remain poorly understood. The present aim of the present study was to test the hypothesis that reactive oxygen species (ROS) enhance osteopontin (OPN) expression and increase matrix metalloproteinase (MMP)-2 activity (two major factors that contribute to restenosis) in aortic vascular smooth muscle cells (VSMC), thus facilitating restenosis. 2. Primary cultured rat… CONTINUE READING
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