Hydrogen peroxide enhances TRAIL-induced cell death through up-regulation of DR5 in human astrocytic cells.

@article{Kwon2008HydrogenPE,
  title={Hydrogen peroxide enhances TRAIL-induced cell death through up-regulation of DR5 in human astrocytic cells.},
  author={Daeho Kwon and KyungSun Choi and Chulhee Choi and Etty Nadia Benveniste},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={372 4},
  pages={
          870-4
        }
}
The central nervous system (CNS) is particularly vulnerable to reactive oxygen species (ROS), which have been implicated in the pathogenesis of various neurological disorders. The TNF superfamily of cytokines, especially tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), induces caspase-dependent cell death and is also implicated in various neurodegenerative diseases. In this study, we investigated the relationship between ROS and TRAIL-induced cell death. Exposure to hydrogen… CONTINUE READING
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