Hydrogen peroxide disrupts scarless fetal wound repair

  title={Hydrogen peroxide disrupts scarless fetal wound repair},
  author={Traci A. Wilgus and Valerie K. Bergdall and Luisa A. DiPietro and Tatiana M. Oberyszyn},
  journal={Wound Repair and Regeneration},
Cutaneous wound healing is a complex process that leads to the formation of a permanent scar in adult skin. In contrast, early gestation fetal skin undergoes scarless repair. Normally, the repair process in the skin begins with an acute inflammatory response. However, one of the most important aspects of scarless fetal wound repair appears to be a lack of inflammation, suggesting that inflammation promotes scar formation in the skin. While it is well accepted that inflammation causes scar… 

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Animal studies and clinical observations have shown that a different type of healing occurs in fetal skin in the first two trimesters of development, which may provide information about how to accelerate postnatal wound healing as well as how to improve healing from a cosmetic standpoint.

The Role of Mast Cells in Fetal Wound Healing

A relationship between mast cell presence and the transition from scarless and fibrotic healing which takes place during development is suggested, which could lead to future studies which could develop new drugs and therapies that may help reduce or even eliminate scar formation in the future.

A Murine Incisional Fetal Wound-Healing Model to Study Scarless and Fibrotic Skin Repair.

  • T. Wilgus
  • Medicine, Biology
    Methods in molecular biology
  • 2021
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Fetal Wound Healing Biomarkers

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Fetal response to injury in the rabbit.

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