Hydrogen peroxide disrupts scarless fetal wound repair

@article{Wilgus2005HydrogenPD,
  title={Hydrogen peroxide disrupts scarless fetal wound repair},
  author={Traci A. Wilgus and Valerie K. Bergdall and Luisa A. DiPietro and Tatiana M. Oberyszyn},
  journal={Wound Repair and Regeneration},
  year={2005},
  volume={13}
}
Cutaneous wound healing is a complex process that leads to the formation of a permanent scar in adult skin. In contrast, early gestation fetal skin undergoes scarless repair. Normally, the repair process in the skin begins with an acute inflammatory response. However, one of the most important aspects of scarless fetal wound repair appears to be a lack of inflammation, suggesting that inflammation promotes scar formation in the skin. While it is well accepted that inflammation causes scar… 
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The aim of this paper is to discuss the main biomarkers involved in fetal skin wound healing as well as their respective mechanisms of action.
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References

SHOWING 1-10 OF 39 REFERENCES
Reduction of scar formation in full‐thickness wounds with topical celecoxib treatment
TLDR
It is suggested that in the absence of infection, adult wound healing is able to commence with decreased inflammation and that anti‐inflammatory drugs may be used to improve the outcome of the repair process in the skin by limiting scar formation.
Studies in fetal wound healing, VI. Second and early third trimester fetal wounds demonstrate rapid collagen deposition without scar formation.
TLDR
A highly sensitive immunohistochemical technique that uses antibodies to collagen types I, III, IV, and VI found that collagen was deposited in fetal wounds much more rapidly than in adult wounds.
A model of scarless human fetal wound repair is deficient in transforming growth factor beta.
TLDR
The role of the cytokine transforming growth factor beta (TGF beta) is studied using an established model of scarless human fetal skin repair in which human fetalskin is transplanted into a subcutaneous pocket on the flank of an adult nude mouse.
Biology of fetal repair: the presence of bacteria in fetal wounds induces an adult-like healing response.
TLDR
Findings suggest that, despite neutropenia and immaturity of the fetal immune system, the fetus is capable of mounting an acute inflammatory response to avirulent bacteria present at the wound site.
TGF-beta1 alters the healing of cutaneous fetal excisional wounds.
TLDR
It is demonstrated that the cytokine TGF-beta1 can induce fetal excisional wounds to contract, stimulate fibrosis, and increase procollagen type 1alpha1 gene expression.
TGF-β1 alters the healing of cutaneous fetal excisional wounds
TLDR
It is demonstrated that the cytokine TGF-β1 can induce fetal excisional wounds to contract, stimulate fibrosis, and increase procllagen type 1α1 gene expression, and further suggest that the absence of TGF -β1 at the wound site may be responsible in part for the lack of a postnatal healing response.
Immunohistochemical localization of growth factors in fetal wound healing.
TLDR
The results suggest that it may be possible to manipulate the adult wound to produce more fetal-like, scarless, wound healing, and the patterns of collagen deposition in both fetal and adult wounds are correlated.
Wound Healing in the PU.1 Null Mouse—Tissue Repair Is Not Dependent on Inflammatory Cells
TLDR
Wound healing studies are reported in the PU.1 null mouse, which is genetically incapable of raising the standard inflammatory response because it lacks macrophages and functioning neutrophils, and it is shown that these "macrophageless" mice are able to repair skin wounds with similar time course to wild-type siblings.
Fetal response to injury in the rabbit.
TLDR
The deposition of extracellular matrix rich in hyaluronic acid but devoid of collagen suggests that the fetal response to injury may be a process more closely resembling regeneration or growth rather than repair by scar deposition.
Exogenous Transforming Growth Factor‐Beta Amplifies Its Own Expression and Induces Scar Formation in a Model of Human Fetal Skin Repair
TLDR
Transforming growth factor- β1 is an important modulator in scar formation and anti-TGF-β1 strategies may promote scarless healing in adult wounds.
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