Hydrogen peroxide detection with high specificity in living cells and inflamed tissues

@inproceedings{Rong2016HydrogenPD,
  title={Hydrogen peroxide detection with high specificity in living cells and inflamed tissues},
  author={Lei Xin Rong and Chi Zhang and Qi Lei and Ming-Ming Hu and Jun Feng and Hong-Bing Shu and Yi Liu and Xianzheng Zhang},
  booktitle={Regenerative biomaterials},
  year={2016}
}
Hydrogen peroxide (H2O2) detection in biological systems is of significant importance, which act as critical second messenger in fundamental biological processes. Here, we report on a chemoselective fluorescent naphthylimide peroxide probe (NPP) for the H2O2 detection in vitro and in vivo. NPP is a phenylboronic acid-caged chromophore that selectively responds to H2O2 through a self-immolate mechanism. NPP exhibited high sensitivity and selectivity to H2O2 with distinctive fluorescence change… CONTINUE READING

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