Hydrogen peroxide decreases pHi in human aortic endothelial cells by inhibiting Na+/H+ exchange.

@article{Hu1998HydrogenPD,
  title={Hydrogen peroxide decreases pHi in human aortic endothelial cells by inhibiting Na+/H+ exchange.},
  author={Qinghua Hu and Y Xia and Stefano Corda and Jay L. Zweier and Roy Charles Ziegelstein},
  journal={Circulation research},
  year={1998},
  volume={83 6},
  pages={644-51}
}
Postischemic endothelial dysfunction may occur as a result of the effects of endogenous oxidants like hydrogen peroxide. Since endothelium-dependent vasodilator function may be affected by pHi, the effect of hydrogen peroxide on endothelial pHi was examined. Hydrogen peroxide (100 micromol/L for 10 minutes) decreased pHi from 7.24+/-0.01 to 7.02+/-0.02 and… CONTINUE READING