Hydrogen peroxide as a cell-survival signaling molecule.

@article{Groeger2009HydrogenPA,
  title={Hydrogen peroxide as a cell-survival signaling molecule.},
  author={Gillian Groeger and Claire Quiney and Thomas G Cotter},
  journal={Antioxidants & redox signaling},
  year={2009},
  volume={11 11},
  pages={
          2655-71
        }
}
Reactive oxygen species (ROS) were seen as destructive molecules, but recently, they have been shown also to act as second messengers in varying intracellular signaling pathways. This review concentrates on hydrogen peroxide (H2O2), as it is a more stable ROS, and delineates its role as a survival molecule. In the first part, the production of H2O2 through the NADPH oxidase (Nox) family is investigated. Through careful examination of Nox proteins and their regulation, it is determined how they… CONTINUE READING
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