Hydrogen peroxide and reoxygenation cause prostaglandin-mediated contraction of human placental arteries and veins.


OBJECTIVE Because our previous studies in several vascular preparations suggest that posthypoxic reoxygenation elicits tone responses by generation of hydrogen peroxide we compared the actions of reoxygenation and hydrogen peroxide on isolated human placental arteries and veins. STUDY DESIGN Endothelium-intact and denuded arteries and veins (1 to 2 mm… (More)