• Chemistry, Medicine
  • Published in
    Cellular and molecular…
    2006
  • DOI:10.1170/T721

Hydrogen peroxide activation of endothelial cell-associated MMPs during VCAM-1-dependent leukocyte migration.

@article{CookMills2006HydrogenPA,
  title={Hydrogen peroxide activation of endothelial cell-associated MMPs during VCAM-1-dependent leukocyte migration.},
  author={Joan M. Cook-Mills},
  journal={Cellular and molecular biology},
  year={2006},
  volume={52 4},
  pages={
          8-16
        }
}
Leukocyte migration from the blood into tissues is vital for immune surveillance and inflammation. Specificity for the site of leukocyte migration is determined by the combination and concentration of adhesion molecules, cytokines and chemokines in the microenvironment. Leukocytes bound at sites of extravasation migrate within minutes. We have focused on the function of the adhesion molecule VCAM-1 and have reported an active function for the endothelium during VCAM- 1-dependent leukocyte… CONTINUE READING

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