Hydrogen peroxide activation of endothelial cell-associated MMPs during VCAM-1-dependent leukocyte migration.

  title={Hydrogen peroxide activation of endothelial cell-associated MMPs during VCAM-1-dependent leukocyte migration.},
  author={Joan M. Cook-Mills},
  journal={Cellular and molecular biology},
  volume={52 4},
  • Joan M. Cook-Mills
  • Published 2006
  • Chemistry, Medicine
  • Cellular and molecular biology
  • Leukocyte migration from the blood into tissues is vital for immune surveillance and inflammation. Specificity for the site of leukocyte migration is determined by the combination and concentration of adhesion molecules, cytokines and chemokines in the microenvironment. Leukocytes bound at sites of extravasation migrate within minutes. We have focused on the function of the adhesion molecule VCAM-1 and have reported an active function for the endothelium during VCAM- 1-dependent leukocyte… CONTINUE READING
    39 Citations
    The Protective Role of Autophagy in Matrix Metalloproteinase-Mediated Cell Transmigration and Cell Death in High-Glucose-Treated Endothelial Cells
    • 13
    • Highly Influenced
    PECAM‐targeted delivery of SOD inhibits endothelial inflammatory response
    • V. Shuvaev, Jingyan Han, +5 authors V. Muzykantov
    • Biology, Medicine
    • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
    • 2011
    • 70
    Role of reactive oxygen and nitrogen species in the vascular responses to inflammation.
    • 190


    VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration.
    • 226
    • PDF
    Molecular mechanisms of leukocyte recruitment in the inflammatory process.
    • K. Ley
    • Biology, Medicine
    • Cardiovascular research
    • 1996
    • 368
    • PDF
    Endothelial Cell E- and P-Selectin and Vascular Cell Adhesion Molecule-1 Function as Signaling Receptors
    • 237
    • PDF