Hydrogen peroxide (H2O2): a review of its use in surgery

@article{Urban2019HydrogenP,
  title={Hydrogen peroxide (H2O2): a review of its use in surgery},
  author={Michael Vincent Urban and Thomas Rath and Christine Radtke},
  journal={Wiener Medizinische Wochenschrift},
  year={2019},
  volume={169},
  pages={222-225}
}
SummaryHydrogen peroxide has been used in medicine for more than 100 years. It is known in surgery as a highly useful irrigation solution by virtue of both its hemostatic and its antimicrobial effects. Due to its possible negative effect on wound healing and its cytotoxic effect in higher concentrations, there are concerns about the safety of its use. The objective of this paper is to review the safety and beneficial effects of hydrogen peroxide.ZusammenfassungWasserstoffperoxid wird in der… 
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References

SHOWING 1-10 OF 43 REFERENCES

Hydrogen peroxide: a review of its use in dentistry.

In patients, prolonged use of hydrogen peroxide decreased plaque and gingivitis indices, however, therapeutic delivery of H2O2 to prevent periodontal disease required mechanical access to subgingival pockets, and wound healing following gingival surgery was enhanced due to the antimicrobial effects of topically administered hydrogenperoxide.

The Use of Hydrogen Peroxide for Achieving Dermal Hemostasis After Burn Excision in a Patient with Platelet Dysfunction

As a topical hemostatic agent, hydrogen peroxide (3%) has been applied to tangential excisions of burn patients and clinically has been most useful in patients with known platelet dysfunction.

A study of hydrogen peroxide generation by, and antioxidant activity of, Granuflex™ (DuoDERM™) Hydrocolloid Granules and some other hydrogel/hydrocolloid wound management materials

The results suggested that Granuflex was undergoing autoxidation in the culture medium, and hence that it might possess antioxidant activity, and certain other hydrocolloids might contribute to the establishment and maintenance of the reducing environment necessary for energy production and hence cell division.

Hydrogen Peroxide and Wound Healing: A Theoretical and Practical Review for Hair Transplant Surgeons

There are not enough data in hair restoration surgery about the use of hydrogen peroxide, and it is unknown and unclear what the optimum dilution should be.

Accidental ingestion of 35% hydrogen peroxide.

A case of a 39-year-old man who inadvertently ingested 250 mL of unlabelled 35% hydrogen peroxide intended for natural health use is presented, representing an emerging source for accidental poisonings.

Efficacy of debridement and wound cleansing with 2% hydrogen peroxide on graft take in the chronic-colonized burn wounds; a randomized controlled clinical trial.

Hydrogen peroxide as a topical hemostatic agent.

Results indicate that hydrogen peroxide is an effective hemostatic agent and reduces the amount of blood and debris trapped within the trabecular bone methylmethacrylate interface.

Antiseptics on Wounds: An Area of Controversy

The authors found that despite cytotoxicty data, most antiseptics have not been shown to clearly impede healing, especially newer formulations like cadexomer� iodine (which speeds healing) and novel silver delivery systems.

Antiseptics and Disinfectants: Activity, Action, and Resistance

Known mechanisms of microbial resistance (both intrinsic and acquired) to biocides are reviewed, with emphasis on the clinical implications of these reports.

H(2)O(2) inhibits alveolar epithelial wound repair in vitro by induction of apoptosis.

H( 2)O(2) inhibits alveolar epithelial wound repair in large part by induction of apoptosis, which may be a promising new approach to improve repair of the alveolars epithelium in patients with acute lung injury.