Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals?

@article{Giorgio2007HydrogenPA,
  title={Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals?},
  author={Marco Giorgio and Mirella Trinei and Enrica Migliaccio and Pier Giuseppe Pelicci},
  journal={Nature Reviews Molecular Cell Biology},
  year={2007},
  volume={8},
  pages={722-728}
}
The reactive oxygen species that are generated by mitochondrial respiration, including hydrogen peroxide (H2O2), are potent inducers of oxidative damage and mediators of ageing. It is not clear, however, whether oxidative stress is the result of a genetic programme or the by-product of physiological processes. Recent findings demonstrate that a fraction of mitochondrial H2O2, produced by a specialized enzyme as a signalling molecule in the pathway of apoptosis, induces intracellular oxidative… 
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References

SHOWING 1-10 OF 86 REFERENCES
Free radicals and antioxidants in normal physiological functions and human disease.
Energy metabolism and oxidative stress
TLDR
The oxidative stress hypothesis states that free radicals produced during cellular respiration damage lipids, proteins, and DNA thereby accelerating the aging process and increasing disease risk, and other factors, such as mitochondrial function, may be important in the production of free radicals and the subsequent effect on aging and disease states.
Hydrogen peroxide: a signaling messenger.
TLDR
This review evaluates the evidence that H2O2 functions as a signaling agent in higher organisms in light of the known biology and biochemistry of H2 O2 and identifies oxidation-dependent steps in signal transduction pathways being uncovered.
Oxidative stress as a causal factor in differentiation and aging: a unifying hypothesis
Redox‐dependent signal transduction
Enhanced catabolism of mitochondrial superoxide/hydrogen peroxide and aging in transgenic Drosophila.
TLDR
The notion that mitochondrial O2*-/H2O2 production at physiological levels is essential for normal biological processes leading to the attainment of a normal lifespan is supported.
Therapeutics against Mitochondrial Oxidative Stress in Animal Models of Aging
  • S. Melov
  • Biology
    Annals of the New York Academy of Sciences
  • 2002
TLDR
A genetic and pharmacological approach is taken in delineating the range of molecular targets that can be oxidatively damaged by mitochondrial ROS and employing the nematode Caenorhabditis elegans to test the hypothesis that effective antioxidant therapy can prolong the life span of an invertebrate.
Redox signaling in cancer biology.
TLDR
This Forum is directed at understanding possible redox signaling mechanisms governing cellular radiation response, tumor growth, and response to therapy, as well as the role of nitric oxide in cancer biology.
Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency.
TLDR
Calorie restriction can induce a peroxisome proliferation-activated receptor coactivator 1 alpha-dependent increase in mitochondria capable of efficient and balanced bioenergetics to reduce oxidative stress and attenuate age-dependent endogenous oxidative damage.
...
...