Hydrogen peroxide, superoxide, and hydroxyl radicals are involved in the phototoxic action of hematoporphyrin derivative against tumor cells.

@article{Chekulayeva2006HydrogenPS,
  title={Hydrogen peroxide, superoxide, and hydroxyl radicals are involved in the phototoxic action of hematoporphyrin derivative against tumor cells.},
  author={Lyudmila V Chekulayeva and Igor Shevchuk and Vladimir A Chekulayev and Kaja Ilmarinen},
  journal={Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer},
  year={2006},
  volume={25 1-2},
  pages={51-77}
}
This study was aimed to estimate the participation of reactive oxygen species (ROS), other than singlet oxygen (1O2), in the antitumor effect of photodynamic therapy (PDT) with hematoporphyrin derivative (HPD) as well as to determine the ability of photoexcited HPD to the formation of protein peroxides that currently are regarded as a new form of ROS. Studies were performed on Ehrlich ascites carcinoma (EAC) cells, which were loaded with HPD in phosphate-buffered saline and then irradiated with… CONTINUE READING