Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis.

  title={Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis.},
  author={Mikihito Kajiya and Kimihiro Sato and Marcelo Jos{\'e} Barbosa Silva and K Ouhara and Phi M. Do and Keelnatham T Shanmugam and Toshihisa Kawai},
  journal={Biochemical and biophysical research communications},
  volume={386 2},
It is well known that some intestinal bacteria, such as Escherichia coli, can produce a remarkable amount of molecular hydrogen (H(2)). Although the antioxidant effects of H(2) are well documented, the present study examined whether H(2) released from intestinally colonized bacteria could affect Concanavalin A (ConA)-induced mouse hepatitis. Systemic antibiotics significantly decreased the level of H(2) in both liver and intestines along with suppression of intestinal bacteria. As determined by… CONTINUE READING

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