Hydrogen exchange and the dynamic structure of proteins

@article{Woodward1982HydrogenEA,
  title={Hydrogen exchange and the dynamic structure of proteins},
  author={Clare Woodward and I. Simon and Erik T{\"u}chsen},
  journal={Molecular and Cellular Biochemistry},
  year={1982},
  volume={48},
  pages={135-160}
}
In native proteins, buried, labile protons undergo isotope exchange with solvent hydrogens, but the kinetics of exchange are markedly slower than in unfolded polypeptides. This indicates that, whereas buried protein atoms are shielded from solvent, the protein fluctuates around the time average structure and occasionally exposes buried sites to solvent. Generally, hydrogen exchange studies are designed to characterize the nature of the fluctuations between conformational substates, to monitor… CONTINUE READING

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Frontiers in Bioorganic Chemistry and Molecular Biology (Anachenko, S.N., ed

  • K. Narita
  • 1980

Dynamic Aspects of Conformation Changes in Biological Macromolecules (Sadron, C., ed

  • D. Reidel, Dordrecht, Holland
  • 1973

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