Hydrogen exchange and the dynamic structure of proteins

  title={Hydrogen exchange and the dynamic structure of proteins},
  author={Clare Woodward and I. Simon and Erik T{\"u}chsen},
  journal={Molecular and Cellular Biochemistry},
In native proteins, buried, labile protons undergo isotope exchange with solvent hydrogens, but the kinetics of exchange are markedly slower than in unfolded polypeptides. This indicates that, whereas buried protein atoms are shielded from solvent, the protein fluctuates around the time average structure and occasionally exposes buried sites to solvent. Generally, hydrogen exchange studies are designed to characterize the nature of the fluctuations between conformational substates, to monitor… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
38 Citations
3 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 38 extracted citations


Publications referenced by this paper.
Showing 1-3 of 3 references

Frontiers in Bioorganic Chemistry and Molecular Biology (Anachenko, S.N., ed

  • K. Narita
  • 1980

Dynamic Aspects of Conformation Changes in Biological Macromolecules (Sadron, C., ed

  • D. Reidel, Dordrecht, Holland
  • 1973

Similar Papers

Loading similar papers…