Hydrogen-deuterium exchange mass spectrometry reveals folding and allostery in protein-protein interactions.

@article{RamrezSarmiento2018HydrogendeuteriumEM,
  title={Hydrogen-deuterium exchange mass spectrometry reveals folding and allostery in protein-protein interactions.},
  author={C{\'e}sar A. Ram{\'i}rez-Sarmiento and Elizabeth A. Komives},
  journal={Methods},
  year={2018},
  volume={144},
  pages={
          43-52
        }
}
Hydrogen-deuterium exchange mass spectrometry (HDXMS) has emerged as a powerful approach for revealing folding and allostery in protein-protein interactions. The advent of higher resolution mass spectrometers combined with ion mobility separation and ultra performance liquid chromatographic separations have allowed the complete coverage of large protein sequences and multi-protein complexes. Liquid-handling robots have improved the reproducibility and accurate temperature control of the sample… CONTINUE READING
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