Hydrogen cyanide generation by μ-opiate receptor activation: possible neuromodulatory role of endogenous cyanide

@article{Borowitz1997HydrogenCG,
  title={Hydrogen cyanide generation by $\mu$-opiate receptor activation: possible neuromodulatory role of endogenous cyanide},
  author={J. Borowitz and P. Gunasekar and G. Isom},
  journal={Brain Research},
  year={1997},
  volume={768},
  pages={294-300}
}
Hydrogen cyanide, a gaseous molecule, is produced by white blood cells during phagocytosis. The present study examined the possibility that neuronal-like cells may also produce cyanide following activation. Rat pheochromocytoma (PC12) cells exhibited a low level of cyanide generation that was significantly increased by mu-opiate agonists (hydromorphone, morphine) and blocked by naloxone. A variety of other agonists including bradykinin, nicotine and glutamate did not generate cyanide in PC12… Expand
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[Acute poisoning with carbon monoxide (CO) and cyanide (CN)].
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