Hydrogen cyanide generation by μ-opiate receptor activation: possible neuromodulatory role of endogenous cyanide

@article{Borowitz1997HydrogenCG,
  title={Hydrogen cyanide generation by $\mu$-opiate receptor activation: possible neuromodulatory role of endogenous cyanide},
  author={Joseph L. Borowitz and Palur G. Gunasekar and Gary E. Isom},
  journal={Brain Research},
  year={1997},
  volume={768},
  pages={294-300}
}
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35 Citations
Background Citations
8
Methods Citations
1

35 Citations

Endogenous generation of cyanide in neuronal tissue: Involvement of a peroxidase system
TLDR
Glycine seems to act at an intracellular site to enhance cyanide production and the process seems to involve a peroxidase mechanism similar to that reported for white blood cells.
Receptor mechanisms mediating cyanide generation in PC12 cells and rat brain
The two faces of cyanide: an environmental toxin and a potential novel mammalian gasotransmitter
TLDR
Cyanide fulfills many of the general criteria as a ‘classical’ mammalian gasotransmitter and shares some common features with the current members of this class: nitric oxide, carbon monoxide, and hydrogen sulfide.
Oxidative stress and cyclooxygenase-2 induction mediate cyanide-induced apoptosis of cortical cells.
TLDR
The data show that cyanide treatment of cortical cells involves increased COX-2 expression, PGE(2) accumulation, and ROS generation, resulting in apoptotic cell death, and increased nitric oxide levels caused by cyanide may directly activate the COx-2 enzyme.
Nitric oxide and histone deacetylases modulate cocaine-induced mu-opioid receptor levels in PC12 cells
TLDR
In the PC12 cell model, both nitric oxide and histone deacetylase activity regulate cocaine-induced MOR expression at both the transcriptional and post-transcriptional levels, suggesting epigenetic mechanisms are implicated in cocaine’s action on MOR expression in neurons.
Neurotoxicological and Behavioral Effects of Cyanide and Its Potential Therapies
The use of the blood agent cyanide (CN) as a military threat agent has been recognized not only historically (Nero and Napoleon III) but also more currently in World War I, World War II, in the…
The role of brain gaseous neurotransmitters in anxiety
TLDR
A possible mechanism of gasotransmitter action at the level of anxiety-related synaptic transmission is presented and brain gasesous neuromediators urgently require further wide ranging studies to clarify their potential value for the current neuropharmacology of anxiety disorders.
A Mitochondria-Specific Fluorescent Probe for Visualizing Endogenous Hydrogen Cyanide Fluctuations in Neurons.
TLDR
A mitochondria-specific coumarin pyrrolidinium-derived fluorescence probe (MRP1) that permits the real-time ratiometric imaging ofHCN in living cells and has proved effective in visualizing different concentrations of exogenous HCN in the mitochondria of HepG2 cells, as well as the imaging of endogenous HCN within neurons.
[Acute poisoning with carbon monoxide (CO) and cyanide (CN)].
  • F. Baud
  • Biology, Medicine
    Therapeutische Umschau. Revue therapeutique
  • 2009
TLDR
A critical analysis of acute CO and CN poisonings evidences that the lone toxicological similarity between CO andCN is their ability to avidly bind iron ions in the different hemoproteins, further supporting different mechanisms of action.
Inhibition by naloxone of promoter activity of the neurofilament gene in SK-N-SH cells.
TLDR
It is suggested that naloxone has the ability to suppress transcriptional activity in some neurons by inhibition by dose-dependent and not reversed by morphine.
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References

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