Hydrogen bonds in protein-DNA complexes: where geometry meets plasticity.

  title={Hydrogen bonds in protein-DNA complexes: where geometry meets plasticity.},
  author={Stavroula A. Coulocheri and Diomidis G Pigis and Kostas A. Papavassiliou and Athanasios G. Papavassiliou},
  volume={89 11},
Recognition of a DNA sequence by a protein is achieved by interface-coupled chemical and shape complementation. This complementation between the two molecules is clearly directional and is determined by the specific chemical contacts including mainly hydrogen bonds. Directionality is an instrumental property of hydrogen bonding as it influences molecular conformations, which also affects DNA-protein recognition. The prominent elements in the recognition of a particular DNA sequence by a protein… CONTINUE READING

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