Hydrogen bonding to the cysteine ligand of superoxide reductase: acid–base control of the reaction intermediates

Abstract

Superoxide reductase (SOR) is a non-heme iron metalloenzyme that detoxifies superoxide radical in microorganisms. Its active site consists of an unusual non-heme Fe2+ center in a [His4Cys1] square pyramidal pentacoordination, with the axial cysteine ligand proposed to be an essential feature in catalysis. Two NH peptide groups from isoleucine 118 and… (More)
DOI: 10.1007/s00775-013-1025-1

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