Hydrogen-bonding-promoted oxidative addition and regioselective arylation of olefins with aryl chlorides.

@article{Ruan2010HydrogenbondingpromotedOA,
  title={Hydrogen-bonding-promoted oxidative addition and regioselective arylation of olefins with aryl chlorides.},
  author={Jiwu Ruan and Jonathan A Iggo and Neil G Berry and Jianliang Xiao},
  journal={Journal of the American Chemical Society},
  year={2010},
  volume={132 46},
  pages={16689-99}
}
The first, general, and highly efficient catalytic system that allows a wide range of activated and unactivated aryl chlorides to couple regioselectively with olefins has been developed. The Heck arylation reaction is likely to be controlled by the oxidative addition of ArCl to Pd(0). Hence, an electron-rich diphosphine, 4-MeO-dppp, was introduced to… CONTINUE READING