Hydrogen bonding between sugar and protein is responsible for inhibition of dehydration-induced protein unfolding.

@article{Allison1999HydrogenBB,
  title={Hydrogen bonding between sugar and protein is responsible for inhibition of dehydration-induced protein unfolding.},
  author={Stephanie D Allison and Bo-bo Chang and Theodore W. Randolph and John F. Carpenter},
  journal={Archives of biochemistry and biophysics},
  year={1999},
  volume={365 2},
  pages={289-98}
}
The nature of the interaction responsible for the inhibition of protein unfolding and subsequent damage by sugars during dehydration is unclear. The relationship between sample moisture content measured by coulometric Karl Fischer titration and the apparent moisture content predicted by the area of the protein side chain carboxylate band at approximately 1580 cm-1 in infrared spectra of dried protein-sugar samples was examined. For samples in which a high level of native protein structure was… CONTINUE READING