Hydrogen Sulfide and Colonic Epithelial Metabolism

@article{Jrgensen2004HydrogenSA,
  title={Hydrogen Sulfide and Colonic Epithelial Metabolism},
  author={J. J{\o}rgensen and P. Mortensen},
  journal={Digestive Diseases and Sciences},
  year={2004},
  volume={46},
  pages={1722-1732}
}
Hydrogen sulfide (HS−) impairs the oxidation of butyrate in colonocytes and is found in excess in feces of patients with ulcerative colitis. The possible pathogenic role of HS− in ulcerative colitis was further investigated. To investigate the metabolic effect of free and bound fecal HS−, isolated rat colonocytes were incubated in the presence of butyrate without and with the addition of (1) HS− in water, (2) sterile filtrates of fecal homogenates supplemented and incubated with HS− and known… Expand

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