Hydrogen Sulfide Protects against Chemical Hypoxia-Induced Injury by Inhibiting ROS-Activated ERK1/2 and p38MAPK Signaling Pathways in PC12 Cells

@inproceedings{Lan2011HydrogenSP,
  title={Hydrogen Sulfide Protects against Chemical Hypoxia-Induced Injury by Inhibiting ROS-Activated ERK1/2 and p38MAPK Signaling Pathways in PC12 Cells},
  author={Aiping Lan and Xinxue Liao and Liqiu Mo and Chuntao Yang and Zhanli Yang and Xiuyu Wang and Fen Hsiang Hu and PeiXi Chen and Jianqiang Feng and Dongdan Zheng and Liangcan Xiao},
  booktitle={PloS one},
  year={2011}
}
Hydrogen sulfide (H(2)S) has been proposed as a novel neuromodulator and neuroprotective agent. Cobalt chloride (CoCl(2)) is a well-known hypoxia mimetic agent. We have demonstrated that H(2)S protects against CoCl(2)-induced injuries in PC12 cells. However, whether the members of mitogen-activated protein kinases (MAPK), in particular, extracellular signal-regulated kinase1/2(ERK1/2) and p38MAPK are involved in the neuroprotection of H(2)S against chemical hypoxia-induced injuries of PC12… CONTINUE READING
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