Hydrogen Sulfide Increases Hypoxia-inducible Factor-1 Activity Independently of von Hippel–Lindau Tumor Suppressor-1 in C. elegans

@article{Budde2010HydrogenSI,
  title={Hydrogen Sulfide Increases Hypoxia-inducible Factor-1 Activity Independently of von Hippel–Lindau Tumor Suppressor-1 in C. elegans},
  author={Mark W. Budde and Mark B Roth},
  journal={Molecular Biology of the Cell},
  year={2010},
  volume={21},
  pages={212 - 217}
}
  • Mark W. Budde, Mark B Roth
  • Published 2010
  • Biology, Medicine
  • Molecular Biology of the Cell
  • In C. elegans, hydrogen sulfide (H2S) exposure results in Hif-1 stabilization. hif-1 is required for survival in H2S and constitutive HIF-1 stabilization confers resistance to H2S. H2S-induced HIF-1 reporter activity appears to be independent of VHL-1, whereas VHL-1 is required for hypoxic regulation of HIF-1 reporter activity. 

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