Hydrogen Peroxide Promotes Aβ Production through JNK-dependent Activation of γ-Secretase*S⃞

@article{Shen2008HydrogenPP,
  title={Hydrogen Peroxide Promotes Aβ Production through JNK-dependent Activation of γ-Secretase*S⃞},
  author={Chengyong Shen and Yongfeng Chen and Huaqing Liu and Kejing Zhang and Ting Zhang and Anning Lin and Naihe Jing},
  journal={The Journal of Biological Chemistry},
  year={2008},
  volume={283},
  pages={17721 - 17730}
}
Accumulation of senile plaques composed of amyloid beta-peptide (Abeta) is a pathological hallmark of Alzheimer disease (AD), and Abeta is generated through the sequential cleavage of amyloid precursor protein (APP) by beta- and gamma-secretase. Although oxidative stress has been implicated in the AD pathogenesis by inducing Abeta production, the underlying… CONTINUE READING