Hydrogen Metabolism in Helicobacter pylori Plays a Role in Gastric Carcinogenesis through Facilitating CagA Translocation

@inproceedings{Wang2016HydrogenMI,
  title={Hydrogen Metabolism in Helicobacter pylori Plays a Role in Gastric Carcinogenesis through Facilitating CagA Translocation},
  author={Ge Wang and Judith Romero-Gallo and St{\'e}phane L. Benoit and M Blanca Piazuelo and R. L. Pacheco Dom{\'i}nguez and Douglas R. Morgan and Richard M Peek and Robert J Maier},
  booktitle={mBio},
  year={2016}
}
UNLABELLED A known virulence factor of Helicobacter pylori that augments gastric cancer risk is the CagA cytotoxin. A carcinogenic derivative strain, 7.13, that has a greater ability to translocate CagA exhibits much higher hydrogenase activity than its parent noncarcinogenic strain, B128. A Δhyd mutant strain with deletion of hydrogenase genes was ineffective in CagA translocation into human gastric epithelial AGS cells, while no significant attenuation of cell adhesion was observed. The… CONTINUE READING
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