Hydrogen/deuterium exchange-protected oligomers populated during Aβ fibril formation correlate with neuronal cell death.

@article{SerraVidal2014HydrogendeuteriumEO,
  title={Hydrogen/deuterium exchange-protected oligomers populated during Aβ fibril formation correlate with neuronal cell death.},
  author={Bernat Serra-Vidal and Llu{\'i}s Pujadas and Daniela Rossi and Eduardo Soriano and Sergio Madurga and Nat{\`a}lia Carulla},
  journal={ACS chemical biology},
  year={2014},
  volume={9 11},
  pages={2678-85}
}
The aggregation of the amyloid-β peptide (Aβ) to form fibrils and plaques is strongly associated with Alzheimer's disease (AD). Although it is well established that this process generates neurotoxicity, it is also heterogeneous with a variety of species being formed during the conversion process. This heterogeneity makes it difficult to detect and characterize each of the aggregates formed, which precludes establishing the specific features responsible for the neurotoxicity observed. Here we… CONTINUE READING