Hydrogels for combination delivery of antineoplastic agents.

  title={Hydrogels for combination delivery of antineoplastic agents.},
  author={Kamal H Bouhadir and Eben Alsberg and David J Mooney},
  volume={22 19},
The systemic delivery of anticancer agents has been widely investigated during the past decade but localized delivery may offer a safer and more effective delivery approach. We have designed and synthesized a novel hydrogel to locally deliver antineoplastic agents, and demonstrate the different types of release that can be achieved from these hydrogels using three model drugs: methotrexate, doxorubicin, and mitoxantrone. Alginate was chemically modified into low molecular weight oligomers and… CONTINUE READING


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