Hydrogels containing rutin intended for cutaneous administration: efficacy in wound healing in rats

  title={Hydrogels containing rutin intended for cutaneous administration: efficacy in wound healing in rats},
  author={J. S. Almeida and D. M. Benvegn{\'u} and N. Boufleur and P. Reckziegel and R. C. S. Barcelos and K. Coradini and L. M. de Carvalho and M. E. Buerger and R. Beck},
  journal={Drug Development and Industrial Pharmacy},
  pages={792 - 799}
  • J. S. Almeida, D. M. Benvegnú, +6 authors R. Beck
  • Published 2012
  • Chemistry, Medicine
  • Drug Development and Industrial Pharmacy
  • Objective: Development of a hydrogel containing rutin at 0.025% (w/w) and evaluation of its in vivo efficacy in cutaneous wound healing in rats. Methods: Hydrogels were prepared using Carbopol Ultrez® 10 NF and an aqueous dispersion of rutin in polysorbate 80. Hydrogels were characterized by means of pH measurement, rheological and spreadability analysis and rutin content determination by liquid chromatography. The in vivo healing effect was evaluated through the regression of skin lesions in… CONTINUE READING
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