Hydrogel swelling as a trigger to release biodegradable polymer microneedles in skin.

@article{Kim2012HydrogelSA,
  title={Hydrogel swelling as a trigger to release biodegradable polymer microneedles in skin.},
  author={Minyoung Kim and Bokyung Jung and Jung-hwan Park},
  journal={Biomaterials},
  year={2012},
  volume={33 2},
  pages={668-78}
}
Biodegradable polymeric microneedles were developed as a method for achieving sustained transdermal drug release. These microneedles have potential as a patient-friendly substitute for conventional sustained release methods. However, they have limitations related to the difficulty of achieving separation of the needles into the skin. We demonstrated that microneedle separation into the skin was mediated by hydrogel swelling in response to contact with body fluid after the needles were inserted… CONTINUE READING