Hydrogel Matrix Entrapping PLGA-Paclitaxel Microspheres: Drug Delivery with Near Zero-Order Release and Implantability Advantages for Malignant Brain Tumour Chemotherapy

@article{Ranganath2009HydrogelME,
  title={Hydrogel Matrix Entrapping PLGA-Paclitaxel Microspheres: Drug Delivery with Near Zero-Order Release and Implantability Advantages for Malignant Brain Tumour Chemotherapy},
  author={Sudhir Hulikal Ranganath and Irene Kee and William B. Krantz and Pierce Kah-Hoe Chow and Chi-Hwa Wang},
  journal={Pharmaceutical Research},
  year={2009},
  volume={26},
  pages={2101-2114}
}
To develop paclitaxel-delivering PLGA microspheres entrapped in a gel matrix with sustained drug release properties and implantability advantages for local glioma chemotherapy. Paclitaxel-loaded PLGA microspheres were fabricated using electrohydrodynamic atomization and entrapped by electrospray and gelation. The physicochemical characterizations were performed using scanning electron microscopy and differential scanning calorimetry. The influence of various parameters on the disintegration… CONTINUE READING

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