Hydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery

@inproceedings{Donnelly2012HydrogelFormingMA,
  title={Hydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery},
  author={Ryan F Donnelly and Thakur Raghu Raj Singh and Martin James Garland and Katarzyna Migalska and Rita J. Majithiya and Cian Michael McCrudden and Prashant Laxman Kole and Tuan Mazlelaa Tuan Mahmood and Helen O McCarthy and Andrew David Woolfson},
  booktitle={Advanced functional materials},
  year={2012}
}
Unique microneedle arrays prepared from crosslinked polymers, which contain no drug themselves, are described. They rapidly take up skin interstitial fluid upon skin insertion to form continuous, unblockable, hydrogel conduits from attached patch-type drug reservoirs to the dermal microcirculation. Importantly, such microneedles, which can be fabricated in a wide range of patch sizes and microneedle geometries, can be easily sterilized, resist hole closure while in place, and are removed… CONTINUE READING
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