Hydrodynamics of hemostasis in sickle-cell disease.

  title={Hydrodynamics of hemostasis in sickle-cell disease.},
  author={Samuel I. A. Cohen and Lakshminarayanan Mahadevan},
  journal={Physical review letters},
  volume={110 13},
Vaso-occlusion, the stoppage of blood flow in sickle-cell disease, is a complex dynamical process spanning multiple time and length scales. Motivated by recent ex vivo microfluidic measurements of hemostasis using blood from sickle-cell patients, we develop a multiphase model that couples the kinetics and hydrodynamics of a flowing suspension of normal and sickled cells in a fluid. We use the model to derive expressions for the cell velocities and concentrations that quantify the hydrodynamics… CONTINUE READING