Hydrodynamics of ageing Bruch's membrane: implications for macular disease.

@article{Starita1996HydrodynamicsOA,
  title={Hydrodynamics of ageing Bruch's membrane: implications for macular disease.},
  author={Carla Starita and Ali Aijaz Hussain and Sergio Pagliarini and John Marshall},
  journal={Experimental eye research},
  year={1996},
  volume={62 5},
  pages={
          565-72
        }
}
The hydrodynamic properties of isolated human Bruch's membrane and choroid were investigated as a function of age and retinal location. Macular and peripheral regions of the fundus showed an exponential decline of hydraulic conductivity with half-lives of 15 and 22 years respectively. Comparison of age profiles for hydraulic conductivity and lipid deposits suggests the involvement of two discrete processes for reduction in transport capability. The first appears to involve 'membrane remodelling… CONTINUE READING
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