Hydrodynamics of Supercritical Antisolvent Precipitation: Characterization and Influence on Particle Morphology

@inproceedings{Carretier2003HydrodynamicsOS,
  title={Hydrodynamics of Supercritical Antisolvent Precipitation: Characterization and Influence on Particle Morphology},
  author={Emilie Carretier and Elisabeth Badens and Pierrette Guichardon and Olivier Boutin and G{\'e}rard Charbit},
  year={2003}
}
The hydrodynamics of a supercritical antisolvent (SAS) precipitation vessel has been investigated so as to dissociate its influence on the morphology of the powder from the influence of physicochemistry. Hydrodynamics characterization experiments were carried out in parallel with SAS precipitations of l-poly(lactic acid) (L-PLA) from methylene chloride solutions under similar conditions. The precipitation vessel behaves as a well-mixed reactor auto-agitated by the introduction of the different… CONTINUE READING

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