Hydrodynamic stretching of single cells for large population mechanical phenotyping.

  title={Hydrodynamic stretching of single cells for large population mechanical phenotyping.},
  author={Daniel R. Gossett and Henry Tse and Serena A. Lee and Yong Jun Ying and Anne G Lindgren and Otto O Yang and J V Subba Rao and Amander T Clark and Dino Di Carlo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 20},
Cell state is often assayed through measurement of biochemical and biophysical markers. Although biochemical markers have been widely used, intrinsic biophysical markers, such as the ability to mechanically deform under a load, are advantageous in that they do not require costly labeling or sample preparation. However, current techniques that assay cell mechanical properties have had limited adoption in clinical and cell biology research applications. Here, we demonstrate an automated… CONTINUE READING
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