Hydrodynamic hyperpolarization of endothelial cells.

  title={Hydrodynamic hyperpolarization of endothelial cells.},
  author={M. Nakache and H. Gaub},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={85 6},
  • M. Nakache, H. Gaub
  • Published 1988
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
The orientation and morphology of the endothelium lining the cardiovascular system may result from hemodynamic forces acting on the endothelial cells. To investigate the flow effects at the membrane level, we have examined the variations of the fluorescence intensity of two membrane-sensitive dyes, merocyanine 540 and bis(1,3-diethylthiobarbiturate)trimethineoxonol, (i) as a function of flow shear stress and (ii) with the onset or cessation of the flow. We found a time-dependent decrease in… Expand
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