Hydrodynamic gene delivery to the pig liver via an isolated segment of the inferior vena cava

Abstract

Hydrodynamic gene delivery is an attractive option for non-viral liver gene therapy, but requires evaluation of efficacy, safety and clinically applicable techniques in large animal models. We have evaluated retrograde delivery of DNA to the whole liver via the isolated segment of inferior vena cava (IVC) draining the hepatic veins. Pigs (18–20 kg weight… (More)
DOI: 10.1038/sj.gt.3303079

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