Hydrocortisone affects the expression of matrix metalloproteinases (MMP-1, -2, -3, -7, and -11) and tissue inhibitor of matrix metalloproteinases (TIMP-1) in human gingival fibroblasts.

@article{Cury2007HydrocortisoneAT,
  title={Hydrocortisone affects the expression of matrix metalloproteinases (MMP-1, -2, -3, -7, and -11) and tissue inhibitor of matrix metalloproteinases (TIMP-1) in human gingival fibroblasts.},
  author={Patr{\'i}cia Ramos Cury and Vera Cavalcanti de Ara{\'u}jo and Fl{\'a}vio Canavez and Cristiane Fumiko Furuse and Ney Soares de Ara{\'u}jo},
  journal={Journal of periodontology},
  year={2007},
  volume={78 7},
  pages={1309-15}
}
BACKGROUND There is a positive correlation between the course of periodontal disease and psychosocial stress status. Stress leads to activation of the hypothalamic-pituitary-adrenal axis, resulting in increased cortisol release. The present study evaluates the effect of two different hydrocortisone concentrations on mRNA expression of matrix metalloproteinases (MMPs) and tissue inhibitor of matrix metalloproteinases (TIMPs) in cultured, human gingival fibroblasts. METHODS Gingival fibroblasts… CONTINUE READING
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