Hydrocortisone 17-butyrate degradation in the presence of micro-organisms.

  title={Hydrocortisone 17-butyrate degradation in the presence of micro-organisms.},
  author={S M Rabouan-Guyon and C M Fauvaud and Ph. Courtois and D M Barth{\`e}s},
  journal={Journal of clinical pharmacy and therapeutics},
  volume={22 1},
OBJECTIVE This study compared the degradation of hydrocortisone 17-butyrate (H17B) in the presence of six different bacteria, commonly found on psoriatic skin. METHOD H17B and its degradation products (hydrocortisone and hydrocortisone 21-butyrate (H21B)) were assayed by HPLC. RESULTS In the absence of micro-organisms, we observed 16.6 +/- 7.1% degradation. In the presence of micro-organisms and otherwise similar conditions, we noted that H17B degradation was not modified by cocci… CONTINUE READING

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