Hydrocodone in postoperative personalized pain management: pro-drug or drug?

@article{Stauble2014HydrocodoneIP,
  title={Hydrocodone in postoperative personalized pain management: pro-drug or drug?},
  author={M. Elaine Stauble and Andrew William Moore and Loralie J. Langman and Mark V. Boswell and Richard N. Baumgartner and Suzanne McGee and Jonathan E. Metry and Saeed A. Jortani},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2014},
  volume={429},
  pages={
          26-9
        }
}
BACKGROUND Genetic variations in enzymes that produce active metabolites from pro-drugs are well known. Such variability could account for some of the clinically observed differences in analgesia and side effects seen in postoperative patients. Using genotyping and quantitation of serum concentrations of hydrocodone and its metabolites, we sought to demonstrate the clinical effects of the metabolites of hydrocodone on pain relief. The objective of the current study was to determine whether… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 11 REFERENCES

The Use of Medicines in the United States: Review

M. Kleinrock
  • 2010
VIEW 2 EXCERPTS