Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation

@inproceedings{Brosnan2014HydrocarbonMW,
  title={Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation},
  author={Robert J Brosnan and Trung Pham},
  booktitle={BMC Pharmacology and Toxicology},
  year={2014}
}
Many anesthetics modulate 3-transmembrane (such as NMDA) and 4-transmembrane (such as GABAA) receptors. Clinical and experimental anesthetics exhibiting receptor family specificity often have low water solubility. We hypothesized that the molar water solubility of a hydrocarbon could be used to predict receptor modulation in vitro. GABAA (α1β2γ2s) or NMDA (NR1/NR2A) receptors were expressed in oocytes and studied using standard two-electrode voltage clamp techniques. Hydrocarbons from 14… CONTINUE READING
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Citations

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