Hydrazine-mediated DNA damage: role of hemoprotein, electron transport, and organic free radicals.

@article{RungeMorris1994HydrazinemediatedDD,
  title={Hydrazine-mediated DNA damage: role of hemoprotein, electron transport, and organic free radicals.},
  author={Melissa Ann Runge-Morris and Ning Wu and Raymond F. Novak},
  journal={Toxicology and applied pharmacology},
  year={1994},
  volume={125 1},
  pages={123-32}
}
The hydrazines represent an important class of xenobiotic agents encountered in the environment, in industrial settings, and in medical therapeutics. Agents with a hydrazine functionality are metabolized to toxic intermediates capable of damaging cellular macromolecules and stimulating proteolysis. Phenylhydrazine (PH), methylhydrazine (MH), hydrazine (HY), and the therapeutic agents phenelzine (PZ) and hydralazine (HD) were examined for their ability to undergo metabolism via HbO2 and to cause… CONTINUE READING

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