Hydrazides as tunable reagents for alkene hydroamination and aminocarbonylation.

Abstract

Benzoic hydrazides (R = Ph), which are remarkably bench and thermally stable reagents (often up to 230 degrees C), afford intramolecular hydroamination products upon heating at high temperatures (120-235 degrees C). A concerted Cope-type hydroamination event, followed by a hydrazide-mediated proton transfer step of the hydrazinium ylide intermediate, is… (More)
DOI: 10.1021/ja902558j

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4 Figures and Tables