Hydration of sickle cells using the sodium ionophore Monensin. A model for therapy.

@article{Clark1982HydrationOS,
  title={Hydration of sickle cells using the sodium ionophore Monensin. A model for therapy.},
  author={Michael R. Clark and Narla Mohandas and Stephen B. Shohet},
  journal={The Journal of clinical investigation},
  year={1982},
  volume={70 5},
  pages={1074-80}
}
Mean cell hemoglobin concentration (MCHC) is thought to have an important influence in sickle cell disease, both through the strong dependence of sickling rates on hemoglobin S concentration, and through the profoundly limiting effect of high MCHC on the rheologic competence of oxygenated, irreversibly sickled cells (ISC). Recent studies have tested the ability of antidiuretic hormone to reduce sickle cell MCHC by reducing plasma sodium (Na) and osmolality. An alternative means of reducing MCHC… CONTINUE READING